Notch 1 Antibody
299€ (0.1 mg)
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935106861
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name
Notch 1 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139789
tested applications
WB, IHC, IF/ICC, FCM, IP
Description
Notch 1 Antibody is a Mouse Monoclonal against Notch 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Notch 1 |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | FCM: 1-4 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | O237 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, IF/ICC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P46531 |
| Gene ID | 4851 |
| Alias | AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1 |
| Background | Antibody anti-NOTCH1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NOTCH1 is a transmembrane receptor of the Notch signaling pathway, which regulates critical processes such as cell fate determination, proliferation, differentiation, and apoptosis during development and tissue homeostasis. Upon ligand binding (e.g., Jagged or Delta-like ligands), the NOTCH1 receptor undergoes proteolytic cleavage, releasing its intracellular domain (NICD). NICD translocates to the nucleus, activating transcription of target genes, including HES and HEY family members, to modulate cell behavior. Dysregulation of NOTCH1 contributes to various diseases, including cancers such as T-cell acute lymphoblastic leukemia (T-ALL), where activating mutations drive aberrant proliferation. In addition, NOTCH1 plays a role in cardiovascular development, neural differentiation, and immune system regulation. Knockout studies reveal embryonic lethality due to disrupted vascular development and neurogenesis, demonstrating its essential role in embryonic and adult tissue homeostasis, cellular differentiation, and oncogenesis.
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