NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody

Product specifications

Primary Antibodies

NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1)

Rabbit

Human

IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Antigen Affinity Chromatography.

20 µl

50 µl

100 µl

200 µl

1 ml

Liquid

ELISA, IHC

PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P26715

3821

NP_002250.1

161555

NKG2,NKG2A,CD159A,NKG2-A/NKG2-B type II integral membrane protein,CD159 antigen-like family member A,NK cell receptor A,NKG2-A/B-activating NK receptor

Antibody anti-KLRC1

RUO

Descripción

Killer Cell Lectin-Like Receptor C1 (KLRC1), also known as NKG2A, is a member of the natural killer (NK) cell receptor family and is primarily expressed on NK cells and certain T cell subsets. KLRC1 forms a heterodimer with CD94, and this complex specifically binds to HLA-E, a non-classical major histocompatibility complex (MHC) class I molecule. Upon ligand binding, KLRC1 transmits inhibitory signals through its immunoreceptor tyrosine-based inhibition motif (ITIM), suppressing the activation of NK cells and preventing cytotoxicity. This mechanism is crucial for maintaining immune tolerance and preventing autoimmunity. KLRC1 expression and activity are finely regulated during immune responses, with higher expression levels often associated with a suppressive immune environment. Research has shown that tumor cells and some pathogens exploit KLRC1-mediated inhibition to evade immune surveillance, making it a target of interest for immunotherapeutic strategies. By blocking KLRC1 signaling, immune activation can be enhanced, potentially improving responses against cancers and chronic infections. Additionally, polymorphisms in the KLRC1 gene have been linked to variations in susceptibility to autoimmune diseases and certain infections, underscoring its significance in immunoregulation and disease pathogenesis.

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NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody

KLRC1 Antibody is a Rabbit Polyclonal antibody against KLRC1. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

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NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody

Rabbit polyclonal antibody against KLRC1 protein. Immunogen region is N-terminal.

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NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq].

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