NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody

Este producto es parte de KLRC - killer cell lectin like receptor C
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221€ (50 µg)

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935106861
info@markelab.com
name
NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx323639
tested applications
ELISA, WB

Description

KLRC1 Antibody is a Rabbit Polyclonal against KLRC1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
NKG2-A/NKG2-B Type II Integral Membrane Protein (KLRC1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P26715
Gene ID
3821
Alias
NKG2,NKG2A,CD159A,NKG2-A/NKG2-B type II integral membrane protein,CD159 antigen-like family member A,NK cell receptor A,NKG2-A/B-activating NK receptor
Background
Antibody anti-KLRC1
Status
RUO

Descripción

Killer Cell Lectin-Like Receptor C1 (KLRC1), also known as NKG2A, is a member of the natural killer (NK) cell receptor family and is primarily expressed on NK cells and certain T cell subsets. KLRC1 forms a heterodimer with CD94, and this complex specifically binds to HLA-E, a non-classical major histocompatibility complex (MHC) class I molecule. Upon ligand binding, KLRC1 transmits inhibitory signals through its immunoreceptor tyrosine-based inhibition motif (ITIM), suppressing the activation of NK cells and preventing cytotoxicity. This mechanism is crucial for maintaining immune tolerance and preventing autoimmunity. KLRC1 expression and activity are finely regulated during immune responses, with higher expression levels often associated with a suppressive immune environment. Research has shown that tumor cells and some pathogens exploit KLRC1-mediated inhibition to evade immune surveillance, making it a target of interest for immunotherapeutic strategies. By blocking KLRC1 signaling, immune activation can be enhanced, potentially improving responses against cancers and chronic infections. Additionally, polymorphisms in the KLRC1 gene have been linked to variations in susceptibility to autoimmune diseases and certain infections, underscoring its significance in immunoregulation and disease pathogenesis.

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