Nicastrin (NCSTN) Antibody
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Description
Nicastrin (NCSTN) Antibody is a Rabbit polyclonal antibody for the detection of Human Nicastrin (NCSTN).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nicastrin (NCSTN) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92542 |
| Gene ID | 23385 |
| NCBI Accession | NP_001277113.1 |
| Background | Antibody anti-NCSTN |
| Status | RUO |
Descripción
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Nicastrin (NCSTN) Antibody
NCSTN Antibody is a Rabbit Polyclonal antibody against NCSTN. This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.
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