NGFR p75 Antibody

Product specifications

Primary Antibodies

NGFR p75

Rabbit

Human

ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by Protein A/G column chromatography.

100 µg

1 mg

Lyophilized

ELISA, WB

Prior to lyophilization: 0.02% NaN3.

Shipped within 7-15 working days.

Store at -20 °C. Avoid repeated freeze/thaw cycles.

No

NM_002507

Tumor necrosis factor receptor superfamily member 16,CD271,P75ntr,TNFRSF16,p75(NTR),Gp80-LNGFR,Low affinity neurotrophin receptor p75NTR

Antibody anti-NGFR

RUO

Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

The nerve growth factor receptor (NGFR), also known as p75^NTR or CD271, is a receptor in the tumor necrosis factor receptor superfamily (TNFRSF) with critical roles in neuronal survival, differentiation, apoptosis, and regenerative processes. NGFR is primarily recognized for binding to nerve growth factor (NGF) but is also responsive to other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NGFR serves as a high-affinity receptor, particularly in conjunction with Trk receptors and sortilin, with functions ranging from promoting neuronal survival to facilitating apoptosis, depending on the cellular context and ligand interaction. NGFR has diverse roles beyond the nervous system, including in immune regulation, inflammatory responses, and tissue repair. In non-neuronal tissues, NGFR is involved in cell survival, migration, and differentiation. Due to its versatile functions, NGFR is implicated in neurodegenerative diseases, peripheral neuropathy, and various cancers, including melanoma and glioblastoma, where it often contributes to tumor progression and resistance to apoptosis.

Related Products

Human NGFR (p75 neurotrophin receptor) ELISA Kit

Ver Producto

NGFR antibody

Ver Producto

Recombinant Human NGFR

Ver Producto