Neuronal Apoptosis Inhibitory Protein (NAIP) Antibody
273€ (200 µl)
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935106861
info@markelab.com
name
Neuronal Apoptosis Inhibitory Protein (NAIP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433009
tested applications
P-ELISA
Description
NAIP Antibody is a Goat Polyclonal antibody against NAIP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuronal Apoptosis Inhibitory Protein (NAIP) |
| Host | Goat |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4671 |
| NCBI Accession | NP_004527.2 |
| Alias | Neuronal apoptosis inhibitory protein,Baculoviral IAP repeat-containing protein 1 |
| Background | Antibody anti-NAIP |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
NLR Family Apoptosis Inhibitory Protein (NAIP) is a member of the NOD-like receptor (NLR) family involved in innate immunity and apoptosis regulation It plays a key role in forming the inflammasome, a multiprotein complex that activates caspase-1 leading to the maturation of IL-1β and IL-18 during immune responses NAIP recognizes bacterial flagellin and type III secretion system components triggering the activation of NLRC4 inflammasomes particularly in macrophages NAIP’s anti-apoptotic role is mediated through inhibition of caspase activity which helps protect cells during stress or infection Dysregulation of NAIP expression has been associated with neurodegenerative diseases such as spinal muscular atrophy (SMA) where deletions or mutations in the NAIP gene contribute to motor neuron degeneration Elevated levels of NAIP have also been observed in cancer cells where it aids in apoptosis resistance and tumor progression highlighting its dual role in survival and immune defense
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