Neuromedin U Receptor 1 (NMUR1) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Neuromedin U Receptor 1 (NMUR1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx311831
Description
NMUR1 Antibody (FITC) is a Rabbit Polyclonal against NMUR1 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuromedin U Receptor 1 (NMUR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9HB89 |
| Gene ID | 10316 |
| OMIM | 604153 |
| Alias | NMUR1,FM-3,FM3,GPC-R,GPR66,NMU1R,SNORF62 |
| Background | Antibody anti-NMUR1 |
| Status | RUO |
Descripción
NMUR1 is a G protein-coupled receptor activated by neuromedin U (NMU), a neuropeptide involved in regulating appetite, energy homeostasis, and inflammation. NMUR1 is primarily expressed in peripheral tissues, including the gastrointestinal tract, lungs, and immune cells, where it mediates NMU’s effects on smooth muscle contraction, inflammation, and immune responses. Upon activation, NMUR1 couples to Gq/11 proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and smooth muscle contraction. NMUR1 plays a role in regulating gut motility, bronchoconstriction, and inflammatory responses, particularly in allergic conditions such as asthma and inflammatory bowel disease (IBD). Dysregulation of NMUR1 signaling contributes to inflammatory and metabolic disorders, where it amplifies immune responses and modulates energy expenditure. NMUR1 antagonists are being investigated for their potential to treat inflammatory diseases, asthma, and obesity, as NMU signaling through NMUR1 influences inflammation, energy balance, and smooth muscle activity.
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