Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody
383.5€ (100 µl)
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935106861
info@markelab.com
name
Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx224204
tested applications
ELISA
Description
Notch3 Antibody is a Mouse Monoclonal against Notch3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UM47 |
| Gene ID | 4854 |
| OMIM | 125310 |
| Alias | CADASIL,CADASIL1,CASIL,IMF2,LMNS,notch receptor 3 |
| Background | Antibody anti-NOTCH3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
NOTCH3 is a receptor in the Notch signaling pathway that primarily regulates vascular smooth muscle cell differentiation, stability, and proliferation. Ligand binding triggers cleavage and release of the NOTCH3 intracellular domain (NICD), which activates gene transcription to maintain vascular integrity. NOTCH3 is highly expressed in arterial smooth muscle cells, where it supports vessel structure and function. Mutations in NOTCH3 cause CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a genetic disorder characterized by recurrent strokes, dementia, and vascular dysfunction due to smooth muscle cell degeneration. NOTCH3 is also implicated in tumor biology, where its dysregulation contributes to cancer cell survival, metastasis, and angiogenesis. Knockout studies show defects in vascular development and smooth muscle cell maintenance, emphasizing its role in vascular homeostasis, cell differentiation, and disease pathology.
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Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).
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