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Neurogenic Locus Notch Homolog Protein 3 (NOTCH3) Antibody
proveedor
Abbexareference
abx032737Tested Applications
ELISA, WB, IHC, IF/ICCreactivity
Mousestatus
RUOclonality
PolyclonalDescripción
NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Mouse
immunogen target
Neurogenic Locus Notch Homolog Protein 3 (NOTCH3)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NOTCH3
dry ice
No
availability
Shipped within 5-10 working days.
alias
CADASIL,CADASIL1,CASIL,IMF2,LMNS,notch receptor 3
uniprot id
NCBI accession
NP_000426.2
note
This product is for research use only.
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