Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Antibody
292.5€ (200 µl)
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Name
Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx433049
Tested Applications
P-ELISA
Description
NOTCH2 Antibody is a Goat Polyclonal antibody against NOTCH2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Immunogen: abx269805 - Internal region: C-ERTPSHSGHLQGEH |
| Host | Goat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q04721 |
| Gene ID | 4853 |
| NCBI Accession | NP_077719.2 |
| OMIM | 102500 |
| Alias | AGS2,HJCYS,hN2,notch receptor 2 |
| Background | Antibody anti-NOTCH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
NOTCH2 is a key receptor in the Notch signaling pathway that regulates cell proliferation, differentiation, and tissue patterning during development. Ligand binding induces proteolytic cleavage, releasing the NOTCH2 intracellular domain (NICD), which activates transcription of target genes to control cell fate decisions. NOTCH2 is particularly critical for organogenesis, including kidney development, where it regulates nephron formation and podocyte differentiation. Dysregulation of NOTCH2 is linked to various pathologies, including Alagille syndrome, where mutations impair liver, heart, and kidney development. NOTCH2 also plays a role in cancer, where aberrant signaling promotes tumorigenesis, particularly in breast, pancreatic, and biliary tract cancers. Knockout models demonstrate defects in kidney morphogenesis, osteoclast development, and hematopoiesis, highlighting NOTCH2’s essential role in organ development, cellular differentiation, and disease progression.
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