Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody (PE)

Este producto es parte de NOTCH - Neurogenic locus notch homolog protein
Product Graph
546€ (100 tests)

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935106861
info@markelab.com
name
Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx414150
tested applications
FCM

Description

Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody (PE) is a Mouse Monoclonal antibody against Neurogenic Locus Notch Homolog Protein 1 (NOTCH1).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Neurogenic Locus Notch Homolog Protein 1 (NOTCH1)
Host
Mouse
Reactivity
Mouse
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
PE
Isotype
IgG1
Purification
Purified
Size 1
100 tests
Form
Lyophilized
Tested Applications
FCM
Buffer
PBS, 1% BSA. Contains sodium azide.
Availability
Shipped within 3-7 working days.
Storage
Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q01705
Alias
AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1
Background
Antibody anti-NOTCH1
Status
RUO

Descripción

NOTCH1 is a transmembrane receptor of the Notch signaling pathway, which regulates critical processes such as cell fate determination, proliferation, differentiation, and apoptosis during development and tissue homeostasis. Upon ligand binding (e.g., Jagged or Delta-like ligands), the NOTCH1 receptor undergoes proteolytic cleavage, releasing its intracellular domain (NICD). NICD translocates to the nucleus, activating transcription of target genes, including HES and HEY family members, to modulate cell behavior. Dysregulation of NOTCH1 contributes to various diseases, including cancers such as T-cell acute lymphoblastic leukemia (T-ALL), where activating mutations drive aberrant proliferation. In addition, NOTCH1 plays a role in cardiovascular development, neural differentiation, and immune system regulation. Knockout studies reveal embryonic lethality due to disrupted vascular development and neurogenesis, demonstrating its essential role in embryonic and adult tissue homeostasis, cellular differentiation, and oncogenesis.

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