Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx433684
tested applications
P-ELISA, IHC, IF/ICC
Description
Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) Antibody is a Goat Polyclonal against Neurogenic Locus Notch Homolog Protein 1 (NOTCH1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 1 (NOTCH1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/8000, IHC: 5 µg/ml, IF/ICC: 5 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Tested Applications | P-ELISA, IHC, IF/ICC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4851, 18128, 25496 |
| NCBI Accession | NP_060087.3 |
| Alias | AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1 |
| Background | Antibody anti-NOTCH1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
NOTCH1 is a transmembrane receptor of the Notch signaling pathway, which regulates critical processes such as cell fate determination, proliferation, differentiation, and apoptosis during development and tissue homeostasis. Upon ligand binding (e.g., Jagged or Delta-like ligands), the NOTCH1 receptor undergoes proteolytic cleavage, releasing its intracellular domain (NICD). NICD translocates to the nucleus, activating transcription of target genes, including HES and HEY family members, to modulate cell behavior. Dysregulation of NOTCH1 contributes to various diseases, including cancers such as T-cell acute lymphoblastic leukemia (T-ALL), where activating mutations drive aberrant proliferation. In addition, NOTCH1 plays a role in cardiovascular development, neural differentiation, and immune system regulation. Knockout studies reveal embryonic lethality due to disrupted vascular development and neurogenesis, demonstrating its essential role in embryonic and adult tissue homeostasis, cellular differentiation, and oncogenesis.
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