Neuregulin 3 (NRG3) Antibody
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Description
Neuregulin 3 Antibody is a Goat Polyclonal antibody against Neuregulin 3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuregulin 3 (NRG3) |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10718, 18183 |
| NCBI Accession | NP_001010848.2 |
| Alias | HRG3,pro-NRG3,Pro-neuregulin-3 membrane-bound isoform |
| Background | Antibody anti-NRG3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Neuregulin 3 (NRG3) is a specialized member of the neuregulin family, characterized by its expression in the central nervous system during key stages of brain development and throughout adulthood. It plays critical roles in cortical formation, neuronal migration, and the establishment of synaptic signaling networks. Acting through ErbB4 receptors, NRG3 is involved in shaping neural circuits that influence cognitive and behavioral functions. Variations in the NRG3 gene have been associated with psychiatric disorders such as schizophrenia and autism spectrum disorders. Its emerging importance in brain development and function makes it a valuable target for investigating neurological and psychiatric conditions, as well as for the development of innovative therapies.
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Human NRG-3(Neuregulin 3) ELISA Kit
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Neuregulin 3 (NRG3) Antibody
NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
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Neuregulin 3 (NRG3) Antibody
NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
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