Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody (PE)
429€ (100 tests)
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Name
Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139772
Tested Applications
FCM
Description
CD56 Antibody is a Mouse Monoclonal against CD56.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Immunogen: KG-1 Human acute myelogenous leukemia cell line. |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 20 µl/100 µl of whole blood or 106 cells. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. The content of a vial (2 ml) is sufficient for 100 tests. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG2a |
| Clone ID | U262 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P13591 |
| Gene ID | 4684 |
| Alias | CD56,NCAM,MSK39,N-CAM-1 |
| Background | Antibody anti-NCAM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, is a member of the immunoglobulin (Ig) superfamily and plays a critical role in cell-cell adhesion, neuronal development, and synaptic plasticity. NCAM1 is a transmembrane glycoprotein with alternative splice variants and glycosylation modifications, including polysialic acid (PSA) attachment, which regulates its function. Structurally, NCAM1 consists of five extracellular Ig-like domains, two fibronectin type III domains, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. NCAM1 is highly expressed in the nervous system, where it facilitates neuronal migration, axonal growth, and the formation of synaptic connections during development. PSA-modified NCAM1 reduces adhesion and promotes neuronal plasticity. In adults, NCAM1 continues to regulate synapse maintenance, memory formation, and neuroregeneration. It is also expressed in other cell types, including natural killer (NK) cells, where it mediates immune recognition.
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