Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody
793€ (1 mg)
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935106861
info@markelab.com
name
Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx415239
tested applications
ELISA, WB, IHC
Description
Neural Cell Adhesion Molecule 1 (CD56) Antibody is a Mouse Monoclonal antibody against Neural Cell Adhesion Molecule 1 (CD56).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P13591 |
| Alias | CD56,NCAM,MSK39,N-CAM-1 |
| Background | Antibody anti-NCAM1 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, is a member of the immunoglobulin (Ig) superfamily and plays a critical role in cell-cell adhesion, neuronal development, and synaptic plasticity. NCAM1 is a transmembrane glycoprotein with alternative splice variants and glycosylation modifications, including polysialic acid (PSA) attachment, which regulates its function. Structurally, NCAM1 consists of five extracellular Ig-like domains, two fibronectin type III domains, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. NCAM1 is highly expressed in the nervous system, where it facilitates neuronal migration, axonal growth, and the formation of synaptic connections during development. PSA-modified NCAM1 reduces adhesion and promotes neuronal plasticity. In adults, NCAM1 continues to regulate synapse maintenance, memory formation, and neuroregeneration. It is also expressed in other cell types, including natural killer (NK) cells, where it mediates immune recognition.
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