Nerve Growth Factor Receptor (NGFR) Antibody (PE)
429€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Nerve Growth Factor Receptor (NGFR) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139786
Tested Applications
FCM
Description
CD271 Antibody is a Mouse Monoclonal against CD271.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Nerve Growth Factor Receptor (NGFR) Immunogen: Purified CD271 protein isolated from Human melanoma cell line A875. |
| Host | Mouse |
| Reactivity | Human, Monkey, Cat, Rabbit, Ferret |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Validated in IHC-P and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Clone ID | M156 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P08138 |
| Gene ID | 4804 |
| Alias | Tumor necrosis factor receptor superfamily member 16,CD271,P75ntr,TNFRSF16,p75(NTR),Gp80-LNGFR,Low affinity neurotrophin receptor p75NTR |
| Background | Antibody anti-NGFR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The nerve growth factor receptor (NGFR), also known as p75^NTR or CD271, is a receptor in the tumor necrosis factor receptor superfamily (TNFRSF) with critical roles in neuronal survival, differentiation, apoptosis, and regenerative processes. NGFR is primarily recognized for binding to nerve growth factor (NGF) but is also responsive to other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NGFR serves as a high-affinity receptor, particularly in conjunction with Trk receptors and sortilin, with functions ranging from promoting neuronal survival to facilitating apoptosis, depending on the cellular context and ligand interaction. NGFR has diverse roles beyond the nervous system, including in immune regulation, inflammatory responses, and tissue repair. In non-neuronal tissues, NGFR is involved in cell survival, migration, and differentiation. Due to its versatile functions, NGFR is implicated in neurodegenerative diseases, peripheral neuropathy, and various cancers, including melanoma and glioblastoma, where it often contributes to tumor progression and resistance to apoptosis.
Productos relacionados
Nerve Growth Factor Receptor (NGFR) Antibody
NGFR Antibody is a Rabbit Polyclonal antibody against NGFR. Nerve growth factor receptor contains an extracellular domai…
Ver producto
Nerve Growth Factor Receptor (NGFR) Antibody
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine resi…
Ver producto
Nerve Growth Factor Receptor (NGFR) Antibody
CD271 Antibody is a Rabbit Polyclonal antibody against Mouse and Rat.…
Ver producto