Nerve Growth Factor Receptor (NGFR) Antibody (FITC)
169€ (20 µg)
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name
Nerve Growth Factor Receptor (NGFR) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx316118
Description
NGFR Antibody (FITC) is a Rabbit Polyclonal against NGFR conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nerve Growth Factor Receptor (NGFR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08138 |
| Gene ID | 4804 |
| NCBI Accession | NP_002498.1, NM_002507.3 |
| OMIM | 162010 |
| Alias | Tumor necrosis factor receptor superfamily member 16,CD271,P75ntr,TNFRSF16,p75(NTR),Gp80-LNGFR,Low affinity neurotrophin receptor p75NTR |
| Background | Antibody anti-NGFR |
| Status | RUO |
Descripción
The nerve growth factor receptor (NGFR), also known as p75^NTR or CD271, is a receptor in the tumor necrosis factor receptor superfamily (TNFRSF) with critical roles in neuronal survival, differentiation, apoptosis, and regenerative processes. NGFR is primarily recognized for binding to nerve growth factor (NGF) but is also responsive to other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NGFR serves as a high-affinity receptor, particularly in conjunction with Trk receptors and sortilin, with functions ranging from promoting neuronal survival to facilitating apoptosis, depending on the cellular context and ligand interaction. NGFR has diverse roles beyond the nervous system, including in immune regulation, inflammatory responses, and tissue repair. In non-neuronal tissues, NGFR is involved in cell survival, migration, and differentiation. Due to its versatile functions, NGFR is implicated in neurodegenerative diseases, peripheral neuropathy, and various cancers, including melanoma and glioblastoma, where it often contributes to tumor progression and resistance to apoptosis.
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