NCAM1 (Isoform 2) Antibody
416€ (200 µl)
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935106861
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name
NCAM1 (Isoform 2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430124
tested applications
P-ELISA, WB, IHC, FCM
Description
NCAM1 (Isoform 2) Antibody is a Goat Polyclonal antibody against NCAM1 (Isoform 2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | NCAM1 (Isoform 2) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/32000, WB: 0.03-0.3 µg/ml, IHC: 5 µg/ml, FCM: 10 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 4684, 24586 |
| NCBI Accession | NP_851996.2 |
| Alias | CD56,NCAM,MSK39,N-CAM-1 |
| Background | Antibody anti-NCAM1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Neural Cell Adhesion Molecule 1 (NCAM1), also known as CD56, is a member of the immunoglobulin (Ig) superfamily and plays a critical role in cell-cell adhesion, neuronal development, and synaptic plasticity. NCAM1 is a transmembrane glycoprotein with alternative splice variants and glycosylation modifications, including polysialic acid (PSA) attachment, which regulates its function. Structurally, NCAM1 consists of five extracellular Ig-like domains, two fibronectin type III domains, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. NCAM1 is highly expressed in the nervous system, where it facilitates neuronal migration, axonal growth, and the formation of synaptic connections during development. PSA-modified NCAM1 reduces adhesion and promotes neuronal plasticity. In adults, NCAM1 continues to regulate synapse maintenance, memory formation, and neuroregeneration. It is also expressed in other cell types, including natural killer (NK) cells, where it mediates immune recognition.
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