N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody
169€ (20 µl)
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Name
N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx322393
Tested Applications
ELISA, WB, IHC
Description
GCNT2 Antibody is a Rabbit Polyclonal against GCNT2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: N-Acetyllactosaminide Beta-1,6-N-Acetylglucosaminyl-Transferase (GCNT2) Immunogen: Recombinant human N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase protein (203-402AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8N0V5 |
| Gene ID | 2651 |
| NCBI Accession | NP_001482.1, NM_001491.2, NP_663624.1, NM_145649.4 |
| OMIM | 600429 |
| Alias | N-acetylglucosaminyltransferase,I-branching enzyme,CCAT,CTRCT13,GCNT2C,GCNT5,IGNT,NACGT1,NAGCT1,ULG3,bA360O19.2,bA421M1.1 |
| Background | Antibody anti-GCNT2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Glucosaminyl (N-acetyl) transferase 2 (GCNT2), also known as the I-branching enzyme, catalyzes the addition of N-acetylglucosamine to linear oligosaccharides, forming the branched I antigen structure that characterizes the I blood group system GCNT2 is predominantly expressed in erythroid cells, epithelial tissues, and during embryonic development, where it is critical for glycan diversity and proper glycoprotein function Mutations in GCNT2 lead to the adult i phenotype, a rare blood group disorder characterized by persistent fetal-type linear glycans, hemolytic anemia, and immune vulnerabilities GCNT2’s activity also influences ocular health, with mutations linked to congenital cataracts and other lens abnormalities Emerging research highlights its role in embryogenesis and cell surface glycosylation, critical for cell signaling, adhesion, and differentiation Dysregulation of GCNT2 expression has further been associated with immune dysfunction and specific cancer pathways, emphasizing its role in glycoprotein branching and cellular homeostasis
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