Myosin Light Chain Kinase, Smooth Muscle (MYLK) Antibody

Este producto es parte de MYLK - myosin light chain kinase
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260€ (50 µg)

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935106861
info@markelab.com
name
Myosin Light Chain Kinase, Smooth Muscle (MYLK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx456171
tested applications
ELISA, WB, IHC

Description

Myosin Light Chain Kinase, Smooth Muscle (MYLK) Antibody is a Rabbit polyclonal antibody for the detection of Human Myosin Light Chain Kinase, Smooth Muscle (MYLK).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Myosin Light Chain Kinase, Smooth Muscle (MYLK)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q15746
Gene ID
4638
NCBI Accession
NP_001308238.1
Alias
KRP,AAT7,MLCK,MLCK1,MMIHS,MYLK1,MMIHS1,MYLK-L,smMLCK,MLCK108,MLCK210,MSTP083,Telokin,Kinase-related protein,Myosin light chain kinase smooth muscle
Background
Antibody anti-MYLK
Status
RUO

Descripción

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This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

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