Myosin Light Chain Kinase, Smooth Muscle (MYLK) Antibody
221€ (50 µg)
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Name
Myosin Light Chain Kinase, Smooth Muscle (MYLK) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx328011
Tested Applications
ELISA, WB
Description
MYLK Antibody is a Rabbit Polyclonal against MYLK.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Myosin Light Chain Kinase, Smooth Muscle (MYLK) Immunogen: Synthesized peptide derived from the Internal region of human MYLK. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15746 |
| Gene ID | 4638 |
| Alias | KRP,AAT7,MLCK,MLCK1,MMIHS,MYLK1,MMIHS1,MYLK-L,smMLCK,MLCK108,MLCK210,MSTP083,Telokin,Kinase-related protein,Myosin light chain kinase smooth muscle |
| Background | Antibody anti-MYLK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Myosin light chain kinase (MYLK) is a crucial enzyme responsible for phosphorylating the regulatory light chain of myosin II, a process essential for modulating smooth muscle contraction and cellular motility. MYLK functions by activating the actomyosin complex, enhancing cross-bridge cycling, and facilitating tension generation in response to calcium-calmodulin signaling. It is highly expressed in smooth muscle cells, endothelial cells, and non-muscle tissues, reflecting its versatile roles in physiological processes like vascular tone regulation, cell migration, and maintaining epithelial barrier integrity. Dysregulation of MYLK activity has been implicated in pathological conditions such as hypertension, asthma, and acute lung injury, where excessive or insufficient contractile responses can disrupt normal tissue function. The gene encoding MYLK produces several isoforms, each tailored to specific tissue types and functional demands, further underscoring its adaptability in diverse cellular environments. MYLK's role in dynamic cytoskeletal organization and mechanical force generation makes it a focus of therapeutic research, especially in the context of cardiovascular and inflammatory diseases.
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