Myosin Binding Protein C, Cardiac (MYBPC3) Antibody
364€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Myosin Binding Protein C, Cardiac (MYBPC3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240043
tested applications
ELISA, IHC
Description
Myosin Binding Protein C, Cardiac (MYBPC3) Antibody is a Rabbit Polyclonal antibody for the detection of MYPC3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Myosin Binding Protein C, Cardiac (MYBPC3) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14896 |
| Alias | FHC,CMH4,CMD1MM,LVNC10,MYBP-C,cMyBP-C,C-protein cardiac muscle isoform,Cardiac MyBP-C,Myosin-binding protein C, cardiac-type |
| Background | Antibody anti-MYBPC3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
MYBPC3 is a crucial component of the sarcomere in cardiac muscles, where it regulates cardiac contractility and stabilizes the structural framework of the thick filament. Through its interactions with myosin and actin, it modulates the force and efficiency of cardiac muscle contraction, playing a central role in maintaining the heart’s mechanical function. Mutations in MYBPC3 are a common genetic cause of hypertrophic cardiomyopathy (HCM), a condition characterized by the abnormal thickening of the heart muscle that can lead to heart failure and arrhythmias. These mutations often result in impaired sarcomere function and contribute to maladaptive cardiac remodeling. Research on MYBPC3 focuses on its role in cardiomyopathy pathogenesis and its potential as a therapeutic target for improving heart function in affected individuals.
Related Products
Human MYBPC3(Myosin-binding protein C, cardiac-type) ELISA Kit
Ver Producto
anti- MYBPC3 antibody
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Ver Producto