Myosin Binding Protein C, Cardiac (MYBPC3) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Myosin Binding Protein C, Cardiac (MYBPC3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx177669
tested applications
WB, IHC
Description
Myosin Binding Protein C, Cardiac (MYBPC3) Antibody is a Rabbit Polyclonal antibody against Myosin Binding Protein C, Cardiac (MYBPC3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Myosin Binding Protein C, Cardiac (MYBPC3) Immunogen: abx650275 - Recombinant MYBPC3 (Met1-Ala328) expressed in E. coli. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.63 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% Sodium azide, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | FHC,CMH4,CMD1MM,LVNC10,MYBP-C,cMyBP-C,C-protein cardiac muscle isoform,Cardiac MyBP-C,Myosin-binding protein C, cardiac-type |
| Background | Antibody anti-MYBPC3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
MYBPC3 is a crucial component of the sarcomere in cardiac muscles, where it regulates cardiac contractility and stabilizes the structural framework of the thick filament. Through its interactions with myosin and actin, it modulates the force and efficiency of cardiac muscle contraction, playing a central role in maintaining the heart’s mechanical function. Mutations in MYBPC3 are a common genetic cause of hypertrophic cardiomyopathy (HCM), a condition characterized by the abnormal thickening of the heart muscle that can lead to heart failure and arrhythmias. These mutations often result in impaired sarcomere function and contribute to maladaptive cardiac remodeling. Research on MYBPC3 focuses on its role in cardiomyopathy pathogenesis and its potential as a therapeutic target for improving heart function in affected individuals.
Related Products
Human Myosin Binding Protein C, Cardiac (MYBPC3) Protein
Human MYBPC3 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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