Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibody
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104242
tested applications
WB, IHC
Description
Polyclonal Antibody to Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Immunogen: abx068118 - Recombinant Mouse MUSK (Cys517-Arg766) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Mouse |
| Assay Type | Concentration: 0.51 mg/ml |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q61006 |
| Gene ID | 18198 |
| Alias | CMS9,FADS,FADS1,Muscle-specific tyrosine-protein kinase receptor,Muscle skeletal receptor tyrosine-protein kinase |
| Background | Antibody anti-MUSK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Muscle-associated receptor tyrosine kinase (MUSK) is a critical protein in the formation and maintenance of the neuromuscular junction (NMJ), the synapse between motor neurons and muscle fibers. MUSK is essential for the proper functioning of the NMJ, playing a pivotal role in the signaling pathways that govern the assembly and stability of this specialized synapse. The NMJ is crucial for muscle contraction and overall motor function, and disruptions in MUSK function can lead to severe neuromuscular diseases. MUSK is encoded by the MUSK gene, located on chromosome 9 in humans. The protein belongs to the receptor tyrosine kinase family and is highly conserved across species, reflecting its essential role in muscle biology. MUSK activation is tightly regulated and involves interactions with several other proteins, including agrin, low-density lipoprotein receptor-related protein 4 (LRP4), and downstream effectors such as rapsyn.
Related Products
Mouse Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Protein
Mouse Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) is a recombinant Mouse protein expressed in E. coli.
Ver Producto