MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Primary Antibodies
Monoclonal
Human
Muscle Skeletal Receptor Tyrosine Kinase (MUSK)
Mouse
Unconjugated
Liquid
ELISA, IHC, IF/ICC
Unpurified ascites.
Ascitic fluid containing 0.03% sodium azide.
100 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
MUSK
No
Shipped within 5-10 working days.
CMS9,FADS,FADS1,Muscle-specific tyrosine-protein kinase receptor,Muscle skeletal receptor tyrosine-protein kinase
This product is for research use only.
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Ver másReceptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction(N...
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