Muscarinic Acetylcholine Receptor M3 (CHRM3) Antibody (FITC)
169€ (20 µg)
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Name
Muscarinic Acetylcholine Receptor M3 (CHRM3) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx303406
Description
CHRM3 Antibody (FITC) is a Rabbit Polyclonal against CHRM3 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Muscarinic Acetylcholine Receptor M3 (CHRM3) Immunogen: Recombinant human Muscarinic acetylcholine receptor M3 protein (253-492AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20309 |
| Gene ID | 1131 |
| OMIM | 118494 |
| Alias | CHRM3,Chrm-3,M3R,cholinergic receptor, muscarinic 3,cholinergic receptor,cholinergic receptor, muscarinic 3, cardiac,M3 receptor,HM3, PBS, EGBRS, m3AChR |
| Background | Antibody anti-CHRM3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CHRM3 encodes the cholinergic receptor muscarinic 3, another receptor in the muscarinic acetylcholine receptor family that primarily couples to Gq/11 proteins. Upon activation by acetylcholine, CHRM3 stimulates phospholipase C (PLC), leading to increased production of inositol triphosphate (IP3) and diacylglycerol (DAG), which together elevate intracellular calcium ion concentrations and activate downstream signaling pathways. CHRM3 is abundantly expressed in smooth muscle tissues of the gastrointestinal tract, bladder, and lungs, where it plays a key role in mediating smooth muscle contraction. It is critical for processes such as gastrointestinal motility, bronchoconstriction, and urinary bladder contraction. In the CNS, CHRM3 contributes to cognitive function and neuronal signaling. Dysregulation of CHRM3 has been implicated in disorders like overactive bladder syndrome, asthma, and certain types of cancer. Pharmacologically, CHRM3 antagonists, such as antimuscarinics, are used to treat conditions like overactive bladder, while agonists could be explored for potential use in cognitive enhancement. CHRM3 remains a critical target for both autonomic regulation and emerging therapies in neurological disorders and cancer research.
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