Mouse Vav 3 Oncogene (VAV3) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits VAV3
proveedor
Abbexareference
abx254710Tested Applications
ELISAreactivity
Mousestatus
RUOclonality
Descripción
Mouse Vav 3 Oncogene (VAV3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Guanine nucleotide exchange factor VAV3 concentrations in serum, plasma and other biological fluids.
Background
VAV3 is a member of the VAV family of guanine nucleotide exchange factors (GEFs) that regulate Rho family GTPases, such as Rac1, RhoA, and Cdc42, to mediate cytoskeletal reorganization, cell migration, and proliferation. VAV3 is expressed in multiple tissues, including the brain, endothelial cells, and immune cells, where it functions in signaling pathways downstream of receptor tyrosine kinases (RTKs), integrins, and immune receptors. It is involved in processes like angiogenesis, neuronal development, and immune cell activation. Dysregulation of VAV3 is associated with cancer, where it promotes tumor cell migration, metastasis, and survival through Rac1 activation and integrin signaling. VAV3 also plays a role in immune responses, including T-cell activation and macrophage function. Knockout studies demonstrate impaired angiogenesis, defective immune cell migration, and reduced tumor metastasis, highlighting its essential role in cytoskeletal regulation, cell signaling, and tumor progression.
Características del producto
category
ELISA Kits
immunogen target
Vav 3 Oncogene (VAV3)
reactivity
Mouse
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.088 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
alias
VAV-3
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
VAV3
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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