Mouse Vascular Endothelial Growth Factor Receptor 2 / VEGFR2 (KDR) Protein
208€ (10 µg)
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name
Mouse Vascular Endothelial Growth Factor Receptor 2 / VEGFR2 (KDR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069651
tested applications
WB, SDS-PAGE
Description
Recombinant Vascular Endothelial Growth Factor Receptor 2 / VEGFR2 (KDR) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vascular Endothelial Growth Factor Receptor 2 / VEGFR2 (KDR) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 32.4 kDa Observed MW (SDS-PAGE): 34 kDa Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Asn46-Thr322 Tag: N-terminal His tag |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration less than or equal to 0.1 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35918 |
| Alias | FLK1,CD309,VEGFR,VEGFR2,VEGFR-2,Protein-tyrosine kinase receptor flk-1,Fetal liver kinase 1,Vascular endothelial growth factor receptor 2 |
| Background | Protein KDR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KDR, also known as vascular endothelial growth factor receptor 2 (VEGFR-2), is a critical protein in the regulation of angiogenesis and vascular development. This receptor tyrosine kinase (RTK) is encoded by the KDR gene located on chromosome 4q12 in humans. KDR is a member of the VEGF receptor family, which plays an essential role in the processes of vasculogenesis and angiogenesis by mediating the cellular responses to the vascular endothelial growth factor (VEGF). The VEGF family consists of several ligands, with VEGF-A being the primary ligand for KDR. KDR is predominantly expressed in endothelial cells, where it regulates vascular permeability, endothelial cell proliferation, migration, and survival. Due to its pivotal role in vascular biology, KDR has been extensively studied in the context of cancer, where angiogenesis is a crucial process for tumor growth and metastasis. KDR's involvement in pathological angiogenesis makes it a significant target for anti-angiogenic therapies in cancer treatment. Moreover, it has implications in other diseases characterized by abnormal vascular growth, such as age-related macular degeneration and rheumatoid arthritis.
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