Mouse UL16 Binding Protein 1 (ULBP1) Protein
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Description
Mouse NKG2D Ligand 1 Protein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse UL16 Binding Protein-1/NKG2D ligand 1 is produced by our Mammalian expression system and the target gene encoding Pro26-Thr211 is expressed with a 6His tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | NKG2D Ligand 1 |
| Host | Human |
| Origin | Mouse |
| Observed MW | Molecular Weight: 22.3 kDa Sequence Fragment: Pro26-Thr211 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mM NaCl, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q8HWA3 |
| Background | Protein ULBP1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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Human ULBP1 (UL16-binding protein 1) ELISA Kit
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ULBP1 antibody
Ligand for the KLRK1/NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
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