Mouse Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Protein
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx680350
Tested Applications
SDS-PAGE
Description
Mouse Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Protein is a recombinant protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Background | Protein UCHL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
Productos relacionados
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
UCHL1 Antibody is a Rabbit Polyclonal antibody against UCHL1. The protein encoded by this gene belongs to the peptidase …
Ver producto
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
Rabbit polyclonal antibody against PGP9.5/UCHL1 protein.…
Ver producto
Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Antibody
UCHL1 Antibody is a Mouse Monoclonal antibody against UCHL1.…
Ver producto