Mouse Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Protein
234€ (2 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Mouse Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073854
tested applications
SDS-PAGE
Description
Ubiquitin Carboxyl-Terminal Esterase L1 is a recombinant enzyme.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Ubiquitin Carboxyl Terminal Hydrolase L1 (UCHL1) |
| Host | Insect |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Mouse |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P50428 |
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Background | Protein UCHL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
Related Products
Human UCHL1(Ubiquitin carboxyl-terminal hydrolase isozyme L1) ELISA Kit
Ver Producto
Mouse UCHL1(Ubiquitin Carboxyl Terminal Hydrolase L1) ELISA Kit
Ver Producto