Mouse Tyrosine-Protein Kinase CSK (CSK) Protein (Active)
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Description
Mouse CSK Protein is a recombinant protein from Mouse produced in Baculovirus-Insect Cells. A DNA sequence encoding the mouse CSK (P41241?) (Met 1-Leu 450) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CSK |
| Host | Insect |
| Assay Type | Activity: Active Sequence Fragment: Met1-Leu450 Tag: N-terminal His tag and GST tag |
| Origin | Mouse |
| Observed MW | 78.5 kDa |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | Supplied as sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| Background | Protein CSK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg of the protein as determined by the LAL method. |
Descripción
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Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
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Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
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