Mouse Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7) Protein

Este producto es parte de CD70 - CD70 molecule
Mouse Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein CD70

proveedor

Abbexa

reference

abx069557

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

CD70, also known as TNFSF7 (Tumor Necrosis Factor Superfamily Member 7), is a transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) ligand superfamily. It is primarily expressed on the surface of activated immune cells, including T cells, B cells, dendritic cells (DCs), and natural killer (NK) cells. The expression of CD70 is tightly regulated and is typically transient, occurring upon immune cell activation, particularly during the adaptive immune response. CD70 plays a crucial role in immune cell interactions, contributing to T cell proliferation, differentiation, and the development of memory T cells. CD70 exerts its effects by binding to its receptor, CD27, which is a member of the TNF receptor superfamily. CD27 is constitutively expressed on naïve T cells, memory T cells, and NK cells, and its interaction with CD70 initiates intracellular signaling pathways that enhance immune activation and memory formation. This CD70-CD27 interaction is critical for effective immune responses, particularly during viral infections, tumor immunity, and in the context of autoimmune diseases.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Tumor Necrosis Factor Ligand Superfamily, Member 7 (TNFSF7)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 15.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu64-Trp192 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

CD70


dry ice

No


availability

Shipped within 5-7 working days.


alias

CD27L,LPFS3,CD27-L,CD27LG,TNFSF7,TNLG8A,CD70 antigen,CD27 ligand 


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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