Mouse Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Protein
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Description
Mouse OX40 Ligand Protein is a recombinant protein from Mouse produced in Human Cells. Recombinant Mouse OX40 Ligand is produced by our Mammalian expression system and the target gene encoding Ser51-Leu198 is expressed with a 8His tag at the N-terminus.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | OX40 Ligand |
| Host | Human |
| Origin | Mouse |
| Observed MW | Molecular Weight: 17.7 kDa Sequence Fragment: Ser51-Leu198 Tag: N-terminal 8 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P43488 |
| Alias | Tumor necrosis factor ligand superfamily member 4,GP34,CD252,OX4OL,TXGP1,CD134L,OX-40L,TNLG2B,OX40 ligand,OX40L,TAX transcriptionally-activated glycoprotein 1 |
| Background | Protein TNFSF4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFSF4, also known as OX40 ligand (OX40L) or CD252, is a member of the tumor necrosis factor (TNF) superfamily. It plays a crucial role in the immune system by interacting with the OX40 receptor (CD134), primarily expressed on activated T cells. This interaction contributes to T-cell activation, proliferation, and survival, and it is particularly important for the adaptive immune response. OX40L is predominantly expressed on activated antigen-presenting cells, such as dendritic cells, B cells, and macrophages, and its role in enhancing T-cell function is integral to immune response against infections, cancer, and during inflammatory processes. OX40L has gained significant attention for its role in immune checkpoint pathways, which are mechanisms that regulate immune response strength and duration. Because of its function in enhancing T-cell activity, it has been studied as a target for immunotherapies in cancer, autoimmune disorders, and infectious diseases. Additionally, dysregulation of the TNFSF4 gene, which encodes OX40L, has been implicated in several inflammatory and autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.
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Recombinant Human OX40L
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Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Antibody
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. This antibody is supplied as crude ascites.
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Tumor Necrosis Factor Ligand Superfamily Member 4 / OX40L (TNFSF4) Antibody
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
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