Mouse Tumor Necrosis Factor (TNF) Protein
proveedor
Abbexareference
abx691359Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse CD27 antigen Protein is a recombinant protein from Mouse produced in E. coli. A DNA sequence encoding the soluble form of mouse TNF-α (NP_038721.1) (Leu 80-Leu 235) was expressed, with an initial Met at the C-terminus.
Background
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
Human
immunogen target
Tumor Necrosis Factor (TNF)
host
Human
form
Lyophilized
tested applications
SDS-PAGE
size 1
20 µg
size 2
100 µg
expression
Recombinant
purity
> 95% (SDS-PAGE)
buffer
PBS, pH7.4.
storage
Store at < -20°C.
or code
TNF
dry ice
No
availability
Shipped within 5-15 working days.
alias
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
uniprot id
NCBI accession
NP_001028298.1
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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