Mouse Transmembrane Emp24 Domain-Containing Protein 2 (TMED2) ELISA Kit
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Description
Mouse Transmembrane emp24 domain-containing protein 2 ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transmembrane emp24 domain-containing protein 2 concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transmembrane Emp24 Domain-Containing Protein 2 (TMED2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | TMED2, RNP24,p24 family protein beta-1,p24beta1 |
| Background | Elisa kits for TMED2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TMED2, a member of the p24 family, functions as a cargo receptor and vesicle trafficking regulator in the early secretory pathway, mediating protein transport between the ER, ER-Golgi intermediate compartment (ERGIC), and Golgi apparatus. It is a key component of the COPII vesicle coat complex, where it assists in the selective packaging and transport of secretory and membrane proteins. TMED2 also regulates the recycling of vesicles back to the ER through interactions with the COPI coat complex, ensuring efficient cargo flow and ER-Golgi communication. It is highly expressed in tissues with active protein secretion and participates in processes such as receptor trafficking, organelle integrity, and cellular homeostasis. Dysregulation of TMED2 has been implicated in developmental defects, metabolic diseases, and cancers, where altered protein sorting disrupts cellular signaling and growth. Knockdown studies show impaired vesicle transport, disrupted Golgi architecture, and ER stress, highlighting its critical role in maintaining vesicular trafficking, protein quality control, and cellular function.
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