Mouse Transferrin Receptor Protein 1 / CD71 (TFRC) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein TFRC
proveedor
Abbexareference
abx069411Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Transferrin Receptor (TFR) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
TFRC, also known as CD71, is a transmembrane glycoprotein that mediates the uptake of transferrin-bound iron into cells via receptor-mediated endocytosis. It plays a crucial role in iron homeostasis, as iron is essential for processes like DNA synthesis, oxygen transport, and energy metabolism. TFRC expression is tightly regulated by cellular iron levels, proliferative demand, and hypoxia, with high expression observed in rapidly dividing cells, such as activated lymphocytes, erythroid progenitors, and cancer cells. Its overexpression is frequently observed in tumors, where increased iron uptake supports cancer cell proliferation and survival. TFRC is also involved in immune regulation and erythropoiesis, with its deficiency leading to anemia, impaired cell growth, and compromised immune responses. Targeting TFRC is being explored in cancer therapy as a mechanism for selective drug delivery and iron deprivation. Knockdown studies show impaired iron metabolism, reduced cell proliferation, and increased sensitivity to oxidative stress, emphasizing its central role in cellular growth, iron transport, and metabolic regulation.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Transferrin Receptor Protein 1 / CD71 (TFRC)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 27.4 kDa Observed MW (SDS-PAGE): 29 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg572-Trp757 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TFRC
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD71,IMD46,T9,TFR,TFR1,TR,TRFR,p90
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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