Mouse Transferrin Receptor Protein 1 / CD71 (TFRC) ELISA Kit
585€ (96 tests)
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935106861
info@markelab.com
name
Mouse Transferrin Receptor Protein 1 / CD71 (TFRC) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx254460
tested applications
ELISA
Description
Mouse Transferrin Receptor Protein 1 / CD71 (TFRC) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Transferrin Receptor Protein 1 / CD71 (TFRC) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transferrin Receptor Protein 1 / CD71 (TFRC) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | 0.38 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q62351 |
| Gene ID | 22042 |
| NCBI Accession | NP_035768.1, XP_006522062.1 |
| Alias | CD71,IMD46,T9,TFR,TFR1,TR,TRFR,p90 |
| Background | Elisa kits for TFRC |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TFRC, also known as CD71, is a transmembrane glycoprotein that mediates the uptake of transferrin-bound iron into cells via receptor-mediated endocytosis. It plays a crucial role in iron homeostasis, as iron is essential for processes like DNA synthesis, oxygen transport, and energy metabolism. TFRC expression is tightly regulated by cellular iron levels, proliferative demand, and hypoxia, with high expression observed in rapidly dividing cells, such as activated lymphocytes, erythroid progenitors, and cancer cells. Its overexpression is frequently observed in tumors, where increased iron uptake supports cancer cell proliferation and survival. TFRC is also involved in immune regulation and erythropoiesis, with its deficiency leading to anemia, impaired cell growth, and compromised immune responses. Targeting TFRC is being explored in cancer therapy as a mechanism for selective drug delivery and iron deprivation. Knockdown studies show impaired iron metabolism, reduced cell proliferation, and increased sensitivity to oxidative stress, emphasizing its central role in cellular growth, iron transport, and metabolic regulation.
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