Mouse TNF Receptor Associated Factor 6 (TRAF6) Protein
Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein TRAF6
proveedor
Abbexareference
abx167387Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
TRAF6 Protein is a recombinant Mouse protein expressed in E. coli.
Background
TRAF6 is a multifunctional adaptor protein that regulates signaling downstream of TNFR superfamily members, Toll-like receptors (TLRs), and IL-1 receptors. It activates key pathways, including NF-κB, JNK, and Akt, to mediate inflammatory responses, innate immunity, and bone homeostasis. TRAF6 also functions as an E3 ubiquitin ligase, facilitating K63-linked ubiquitination of signaling intermediates like TAK1, IKK, and Akt to promote downstream activation. It plays essential roles in immune cell activation, osteoclast differentiation, and autophagy regulation. TRAF6 is widely expressed in immune cells, bone tissue, and epithelial cells, where it supports pathogen recognition, inflammatory signaling, and bone remodeling. Dysregulation of TRAF6 is associated with autoimmune diseases, chronic inflammation, osteoporosis, and cancer due to hyperactive NF-κB signaling and impaired bone resorption. Knockout models exhibit immune deficiencies, defective TLR signaling, impaired bone development, and increased susceptibility to infections, underscoring its critical role in immunity, inflammation, and skeletal homeostasis.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
TNF Receptor Associated Factor 6 (TRAF6)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln254-Asn475 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TRAF6
dry ice
No
availability
Shipped within 5-7 working days.
alias
TRAF-6,TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human TRAF6(TNF receptor-associated factor 6) ELISA Kit
proveedor
FineTestreference
EH2402reactivity
humanstatus
RUOPrecio a consultar
Ver másanti- TRAF6 antibody
proveedor
FineTestreference
FNab08921Tested Applications
ELISA, WB, IHC, IFreactivity
human,mouse,ratstatus
RUOclonality
polyclonalE3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains...
Precio a consultar
Ver másTNF Receptor-Associated Factor 6 (TRAF6) Antibody
proveedor
Abbexareference
abx000926Tested Applications
IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalTRAF6 Antibody is a Rabbit Polyclonal antibody against TRAF6. The protein encoded by this gene is a member of the TNF re...
312€ (60 µl)
Ver más