Mouse TNF Receptor Associated Factor 2 (TRAF2) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse TNF Receptor Associated Factor 2 (TRAF2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx167388
Tested Applications
WB, SDS-PAGE
Description
Mouse TNF Receptor Associated Factor 2 Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | TNF Receptor Associated Factor 2 (TRAF2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gln238-Phe491 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 32.4 kDa Observed MW (SDS-PAGE): 32 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | TRAF-2,TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117 |
| Background | Protein TRAF2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
TRAF2 is a key adaptor protein that links TNF receptors and other immune receptors to downstream signaling pathways, particularly NF-κB and JNK activation, to regulate inflammation, cell survival, and apoptosis. TRAF2 interacts with TNFR1, TNFR2, and CD40 to recruit signaling intermediates like RIPK1 and IKK, facilitating the activation of NF-κB-dependent transcription of pro-survival and pro-inflammatory genes. It plays a critical role in immune homeostasis and inflammation, particularly in T cells, B cells, and macrophages. TRAF2 also regulates apoptosis by inhibiting caspase-8 activation through recruitment of cIAP proteins. Dysregulation of TRAF2 is implicated in autoimmune diseases, chronic inflammatory conditions, and cancers, where excessive or impaired NF-κB signaling contributes to disease pathogenesis. Knockout studies reveal embryonic lethality, defective TNF-induced NF-κB activation, and increased apoptosis, highlighting its essential role in maintaining cell survival and immune responses.
Productos relacionados
TNF Receptor Associated Factor 2 (TRAF2) Antibody
TRAF2 Antibody is a Rabbit Polyclonal antibody against TRAF2. The protein encoded by this gene is a member of the TNF re…
Ver producto
TNF Receptor Associated Factor 2 (TRAF2) Antibody
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins …
Ver producto
TNF Receptor Associated Factor 2 (TRAF2) Antibody
TNF Receptor Associated Factor 2 Antibody is a Rabbit Polyclonal against TNF Receptor Associated Factor 2.…
Ver producto