Mouse Thyrotropin-Releasing Hormone Receptor (TRHR) ELISA Kit
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Description
Mouse Thyrotropin-Releasing Hormone Receptor (TRHR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse TRHR concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Thyrotropin-Releasing Hormone Receptor (TRHR) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P21761 |
| Gene ID | 22045 |
| Alias | TRHR,TRH receptor,thyroliberin receptor,TRH-R,TRH-R1,CHNG7 |
| Background | Elisa kits for TRHR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The Thyrotropin-Releasing Hormone Receptor (TRHR) is a G protein-coupled receptor (GPCR) that is activated by thyrotropin-releasing hormone (TRH), a peptide hormone responsible for regulating the secretion of thyroid-stimulating hormone (TSH) from the pituitary gland. TRHR is primarily expressed in the anterior pituitary, where it plays a critical role in the regulation of thyroid function by stimulating the release of TSH. Upon activation, TRHR couples to Gq proteins, stimulating phospholipase C (PLC) and increasing intracellular calcium levels, which in turn promotes the release of TSH and the synthesis of thyroid hormones (T3 and T4). TRHR also plays a role in regulating metabolic processes, growth, and development. Dysregulation of TRHR signaling is implicated in disorders such as hypothyroidism, hyperthyroidism, and thyroid tumors. Targeting TRHR with agonists or antagonists can be useful for managing thyroid-related conditions and regulating thyroid hormone production.
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