Mouse T-Cell Surface Protein Tactile (CD96) Protein (Active)
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse T-Cell Surface Protein Tactile (CD96) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692423
tested applications
SDS-PAGE
Description
Mouse CD96 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse CD96 (Q3U0X8) extracellular domain (Met 1-Met 536) was expressed, fused with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD96 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 58 kDa Sequence Fragment: Met1-Met536 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q3U0X8 |
| Alias | T-cell surface protein tactile,TACTILE,T cell-activated increased late expression protein |
| Background | Protein CD96 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The CD96 molecule, also known as TACTILE (T-cell-activated increased late expression), is a transmembrane glycoprotein predominantly expressed on the surface of NK cells and certain subsets of T cells. This protein plays a crucial role in the regulation of immune responses, specifically within the innate immune system, by modulating the activity of NK cells. CD96 is part of the immunoglobulin superfamily and is closely related to other checkpoint receptors such as TIGIT (T cell immunoreceptor with Ig and ITIM domains) and CD226. It has structural and functional similarities with these receptors, which are involved in immune cell interactions and responses to cellular stress signals, infection, and malignant transformations. CD96 binds to the ligand CD155, also known as poliovirus receptor (PVR), which is broadly expressed on various cell types, including endothelial cells and tumor cells. Through its interaction with CD155, CD96 modulates NK cell cytotoxicity and plays a part in controlling the inflammatory response and immunological synapse formation between NK cells and target cells. By balancing activating and inhibitory signals, CD96 ensures immune homeostasis, minimizing the risk of autoimmune responses while enabling effective pathogen and tumor surveillance.
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