Mouse T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8a) Protein (Active)
1079€ (50 µg)
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935106861
info@markelab.com
name
Mouse T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8a) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691615
tested applications
SDS-PAGE
Description
Mouse CD8a Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse CD8a (NP_001074579.1) (Met 1-Tyr 196) was expressed, with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD8a |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 20.3 kDa Sequence Fragment: Met1-Tyr196 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_001074579.1 |
| Alias | CD8,p32,Leu2,IMD116,CD8alpha,MAL,T-lymphocyte differentiation antigen T8/Leu-2,T-cell surface glycoprotein CD8 alpha chain |
| Background | Protein CD8A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The CD8A gene encodes the alpha subunit of the CD8 glycoprotein, a key co-receptor expressed on the surface of cytotoxic T lymphocytes (CD8+ T cells). CD8A typically forms a heterodimer with CD8B or a homodimer (CD8αα). This protein plays a central role in T-cell activation and immune surveillance by interacting with MHC class I molecules on antigen-presenting cells. The interaction stabilizes the binding of the T-cell receptor (TCR) to antigenic peptides presented by MHC class I, facilitating signal transduction and T-cell-mediated cytotoxic responses. CD8A expression is essential for the development and maturation of CD8+ T cells in the thymus. It also participates in the immune response against viral infections, tumors, and intracellular pathogens. Mutations or dysregulation of CD8A can impair T-cell function and immune homeostasis.
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