Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein
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935106861
info@markelab.com
Precio
195€ (10 µg)
Protein SOCS3
proveedor
Abbexareference
abx069208Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
Suppressors Of Cytokine Signaling 3 (SOCS3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 26.3 kDa Observed MW: 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Leu225 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SOCS3
dry ice
No
availability
Shipped within 5-7 working days.
alias
CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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