Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein

Este producto es parte de SOCS - Suppressor of cytokine signaling
Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) Protein

Pida mas información

935106861

info@markelab.com

Precio

195€ (10 µg)

Protein SOCS3

proveedor

Abbexa

reference

abx069208

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Mouse Suppressors Of Cytokine Signaling 3 (SOCS3) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

Suppressors Of Cytokine Signaling 3 (SOCS3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 26.3 kDa Observed MW: 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Leu225 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

SOCS3


dry ice

No


availability

Shipped within 5-7 working days.


alias

CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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