Mouse Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit

Este producto es parte de SOCS - Suppressor of cytokine signaling
Mouse Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit
611€ (96 tests)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

Name
Mouse Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx254430
Tested Applications
ELISA

Description

Mouse Suppressors of Cytokine Signaling 3 (SOCS3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Suppressors of Cytokine Signaling 3 (SOCS3) concentrations in serum, plasma and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Suppressors of Cytokine Signaling 3 (SOCS3)
Reactivity
Mouse
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.16 ng/ml - 10 ng/ml
Sensitivity
0.1 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Serum, plasma and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
O35718
Gene ID
12702
NCBI Accession
NP_031733.1, XP_011247009.1
Alias
CIS3,SSI3,ATOD4,Cish3,SSI-3,SOCS-3
Background
Elisa Kits for: SOCS3
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

SOCS3 is a key negative regulator of cytokine signaling that inhibits JAK/STAT signaling pathways by binding to cytokine receptors, such as the IL-6 and leptin receptors, and targeting them for proteasomal degradation. It directly suppresses JAK kinase activity, preventing STAT phosphorylation and downstream signaling, which controls processes like inflammation, immune cell activation, and energy homeostasis. SOCS3 is highly expressed in immune cells, adipose tissues, and liver, where it modulates cytokine responses, insulin sensitivity, and metabolic regulation. It is critical for limiting excessive inflammation during infections and preventing chronic inflammatory diseases. Dysregulation of SOCS3 is implicated in autoimmune diseases, metabolic disorders like obesity and insulin resistance, and cancer, where it affects cytokine balance and cellular proliferation. Knockout studies reveal embryonic lethality, hyperactivated cytokine signaling, and increased susceptibility to inflammatory and metabolic diseases, underscoring its pivotal role in immune regulation and cytokine signaling control.

Productos relacionados

abx000829

Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. This gene encodes a member of the STAT-induced STAT inhibi…

Ver producto
abx000853

Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

SOCS3 Antibody is a Rabbit Polyclonal antibody against SOCS3. The suppressor of cytokine signaling (SOCS) family protein…

Ver producto
abx036981

Suppressors of Cytokine Signaling 3 (SOCS3) Antibody

Rabbit Polyclonal against the SOCS3 protein.…

Ver producto