Mouse 14-3-3 Protein Sigma (SFN) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Mouse 14-3-3 Protein Sigma (SFN) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069176
Tested Applications
WB, SDS-PAGE
Description
Mouse 14-3-3 Protein Sigma (SFN) is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | 14-3-3 Protein Sigma (SFN) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Ser248 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 31.5 kDa Observed MW (SDS-PAGE): 33 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | O70456 |
| Alias | SFN, YWHAS, Stratifin,14-3-3σ protein |
| Background | Protein SFN |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU/µg (determined by the LAL method) Concentration: Prior to lyophilization: 200 µg/ml |
Background
Stratifin (SFN) , also known as 14-3-3 sigma, is a member of the 14-3-3 protein family that acts as a critical regulator of cell cycle progression, DNA damage response, and cellular stress. It binds to phosphorylated serine/threonine residues on target proteins, facilitating their localization, stability, and activity. Stratifin is specifically involved in G2/M cell cycle checkpoint control by sequestering cyclin-dependent kinase complexes like CDC25C in the cytoplasm, preventing premature mitotic entry under DNA damage conditions. It is highly expressed in epithelial tissues and is essential for maintaining epithelial cell integrity, polarity, and stress responses. Stratifin acts as a tumor suppressor by inhibiting uncontrolled proliferation; its downregulation has been observed in breast, lung, and gastrointestinal cancers due to epigenetic silencing. Functional studies reveal its role in mediating stress-induced growth arrest and apoptosis, underscoring its importance in tumor suppression, DNA repair, and cell cycle regulation.
Productos relacionados
14-3-3 Protein Sigma (SFN) Antibody
SFN Antibody is a Rabbit Polyclonal antibody against SFN. 14-3-3 proteins regulate many cellular processes relevant to c…
Ver producto
14-3-3 Protein Sigma (SFN) Antibody
This product is currently in development. The lead time for this product may be several months. Please contact us at…
Ver producto
14-3-3 Protein Sigma (SFN) Antibody
SFN Antibody is a Rabbit Polyclonal antibody against SFN.…
Ver producto