Mouse Sphingosine 1 Phosphate Receptor 5 (S1PR5) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Mouse Sphingosine 1 Phosphate Receptor 5 (S1PR5) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx494702
tested applications
CLIA
Description
Mouse Sphingosine 1 Phosphate Receptor 5 (S1PR5) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Sphingosine 1 Phosphate Receptor 5 (S1PR5) |
| Reactivity | Mouse |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.059 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | S1PR5,EDG8,Edg-8,S1P5,SPPR-1,SPPR-2,endothelial differentiation G protein-coupled receptor 8,nerve growth factor-regulated G-protein-coupled receptor 1 |
| Background | CLIA Kits S1PR5 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
S1PR5 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), predominantly expressed in oligodendrocytes, natural killer (NK) cells, and endothelial cells. S1PR5 couples to Gi and G12/13 proteins, regulating pathways involved in cell migration, proliferation, and survival. In the central nervous system, S1PR5 plays a critical role in oligodendrocyte differentiation and myelination, contributing to neuronal protection and repair. It also regulates NK cell trafficking and activity, enhancing immune surveillance and anti-tumor responses. Dysregulation of S1PR5 signaling is implicated in neurodegenerative diseases, such as multiple sclerosis, where impaired myelination contributes to disease pathology. In cancer, S1PR5 expression is linked to immune evasion and tumor progression, particularly through modulation of NK cell function. S1PR5 agonists are being developed as therapies for multiple sclerosis to promote remyelination and reduce neuroinflammation, while its role in immune cell regulation makes it a promising target for cancer immunotherapy and inflammatory diseases.
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