Mouse Sphingosine 1 Phosphate Receptor 2 (S1PR2) CLIA Kit

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
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845€ (96 tests)

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935106861
info@markelab.com
name
Mouse Sphingosine 1 Phosphate Receptor 2 (S1PR2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx494697
tested applications
CLIA

Description

Mouse Sphingosine 1 Phosphate Receptor 2 (S1PR2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
CLIA Kits
Immunogen Target
Sphingosine 1 Phosphate Receptor 2 (S1PR2)
Reactivity
Mouse
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.312 ng/ml - 20 ng/ml
Sensitivity
< 0.114 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
S1PR2,AGR16,DFNB68,EDG-5,EDG5,Gpcr13,H218,LPB2,S1P2,endothelial differentiation G protein-coupled receptor 5,G protein-coupled receptor 13,GPCR18 ,S1P receptor 2
Background
CLIA Kits S1PR2
Status
RUO
Note
The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

S1PR2 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), a bioactive lipid that regulates cell migration, proliferation, and vascular integrity. S1PR2 is expressed in endothelial cells, smooth muscle cells, and immune cells, where it couples primarily to G12/13 and Gq proteins. Its activation triggers downstream pathways, including Rho/ROCK and phospholipase C (PLC), leading to actin cytoskeletal reorganization and calcium signaling. S1PR2 plays critical roles in maintaining vascular tone, regulating endothelial barrier integrity, and inhibiting cell migration. It also contributes to immune cell retention in tissues, modulating inflammation and immune responses. Dysregulation of S1PR2 has been linked to inflammatory diseases, cardiovascular dysfunction, and neurodegeneration. In cancer, S1PR2 can act as a tumor suppressor by inhibiting migration and metastasis; however, in some contexts, it promotes inflammation and tumor progression. Targeting S1PR2 is under investigation for therapeutic applications in inflammation, vascular diseases, and cancer.

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