Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) Protein

Este producto es parte de S1PR - Sphingosine 1 Phosphate Receptor
Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) Protein
221€ (10 µg)

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Name
Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx655114
Tested Applications
WB, SDS-PAGE

Description

Mouse Sphingosine 1 Phosphate Receptor 1 (S1PR1) Protein is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Sphingosine 1 Phosphate Receptor 1 (S1PR1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Tyr311-Ser382
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 11.6kD  Observed MW (SDS-PAGE): 16 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
S1PR1,CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,S1P1,endothelial differentiation G protein-coupled receptor 1
Background
Protein S1PR1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

S1PR1 is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid involved in immune regulation, vascular development, and cellular migration. S1PR1 is widely expressed in endothelial cells, lymphocytes, and smooth muscle cells, where it regulates vascular barrier integrity, immune cell trafficking, and angiogenesis. Activation of S1PR1 by S1P triggers signaling pathways involving Gi proteins, leading to activation of PI3K/Akt, MAPK, and Rac, which regulate cell survival, proliferation, and cytoskeletal dynamics. In the immune system, S1PR1 is critical for lymphocyte egress from lymphoid tissues into circulation, making it a key target for immunosuppressive therapies, such as fingolimod, used in treating multiple sclerosis. In the vasculature, S1PR1 maintains endothelial barrier function and regulates vascular permeability. Dysregulation of S1PR1 signaling is associated with inflammatory diseases, cardiovascular disorders, and cancer, where it promotes tumor angiogenesis and immune evasion. Therapeutically, S1PR1 modulators are being developed for autoimmune diseases, inflammatory conditions, and cancer, highlighting its critical role in immune and vascular homeostasis.

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