Mouse Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein

Este producto es parte de SAT - Spermidine/Spermine N1-Acetyltransferase
Mouse Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein
208€ (10 µg)

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Name
Mouse Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx655107
Tested Applications
WB, SDS-PAGE

Description

Mouse Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein is a recombinant Mouse protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Met1-Glu171
Tag: N-terminal His tag
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Calculated MW: 23.7 kDa  Observed MW (SDS-PAGE): 24 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1,Diamine acetyltransferase 1
Background
Protein SAT1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

Spermidine/Spermine N1 Acetyltransferase 1 (SAT1) is a key enzyme involved in polyamine catabolism, catalyzing the acetylation of spermidine and spermine to produce acetylated derivatives that can be further metabolized or exported from the cell SAT1 regulates cellular polyamine levels, which are critical for processes such as DNA replication, transcription, translation, and cell growth Its activity is tightly controlled to maintain polyamine homeostasis, as imbalances can lead to cell death or uncontrolled proliferation Dysregulation of SAT1 has been associated with various conditions, including cancer, where altered polyamine metabolism supports tumor growth and survival SAT1 is also implicated in neurodegenerative disorders and oxidative stress responses, as polyamine metabolism influences reactive oxygen species (ROS) production and cellular damage Additionally, mutations or overexpression of SAT1 are linked to X-linked disorders such as Snyder-Robinson syndrome, characterized by intellectual disabilities and skeletal abnormalities SAT1 plays an emerging role as a potential therapeutic target for modulating polyamine metabolism in cancer and neurological diseases

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